WebOct 1, 2024 · Author summary Genotype imputation estimates the genotypes of unobserved variants using the genotype data of other observed variants based on a collection of genome data of a large number of individuals called a reference panel. In general, more accurate imputation results are obtained using a larger size of the … WebJul 1, 2010 · Genotype imputation is a computational and economical technique that enables the genotype of genetic variants which, for example, have been discarded during the quality control (QC) steps to be ...
Genotype imputation - PubMed
WebThis article reviews the general concepts behind imputation, describes imputation approaches and methods for various types of genotype data, including family-based … WebThrough a rigorous review process, the ASHG Program Committee assembles the best program possible on a diverse set of topics in human genetics. ... Genotype Imputation, and Data Analysis Topic: Statistical Genetics and Genetic Epidemiology Target Audience: Attendees interested in learning how to perform genotype imputation and use imputed ... eva marcille weight
Genotype Imputation from Large Reference Panels - PubMed
WebOct 4, 2024 · The current state-of-the-art genotype imputation quality metric, denoted as standard Rsq, is poorly calibrated for lower-frequency variants. ... The aim of this work is to review state-of-the-art ... WebSep 22, 2024 · Despite the widespread use of genotype imputation tools and the availability of different approaches, late developments of currently used programs have not been compared comprehensively. We therefore assessed the performance of 35 combinations of phasing and imputation programs, including versions of SHAPEIT, … eva margrethe ballo