Cisplatin induced nephrotoxicity mechanism

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August undefined, 2024

WebThe proteinuria associated with cisplatin nephrotoxicity is attributed to a tubular defect. 32 Hemolytic uremic syndrome has also been described, especially when cisplatin is combined with bleomycin. 33 Sequential … WebCisplatin (cis-diamminedichloroplatinum (II), DDP) is an antineoplastic agent widely used in the treatment of solid tumors because of its extensive cytotoxic activity. However, the main limiting side effect of DDP use is nephrotoxicity, a rapid deterioration in kidney function due to toxic chemicals. Several studies have shown that epigenetic processes are involved in …

Cisplatin nephrotoxicity - UpToDate

WebDiscussion. In a previous study, we showed that DM was the high-risk factor for cisplatin-induced AKI. 5 However, no attempt was made to identify the mechanism for the development of AKI in patients with DM. MATE1/SLC47A1, an organic cation transporter in proximal tubular epithelial cells, mediates the tubular secretion of cationic drugs or … Webrotection against gentamicin-induced nephrotoxicity in rats (Sandhya et al. 1995). Interestingly, the dose of an antioxi-dant lipoic acid (0.12–0.48 mmole/kg) required to protect cisplatin-induced nephrotoxicity (16 mg/kg) in rats was three to twelve times less than that of a chelating agent 4- baseball park ozark mo

Cisplatin nephrotoxicity: insights into mechanism - PubMed

WebCisplatin is a widely used and highly effective cancer chemotherapeutic agent. One of the limiting side effects of cisplatin use is nephrotoxicity. Research over the past 10 years … WebOct 11, 2024 · Experimentally induced sepsis (via LPS) also potentiates the degree of cisplatin-induced hearing loss in mice (Oh et al., 2011). LPS-induced inflammation in … WebFeb 2, 2024 · Some studies have found that vinorelbine protects against cisplatin-induced acute kidney injury (AKI) by activating Nrf2/HO-1 signaling pathway and hindering TLR4-IFN-γ-CD44 cell inflammatory cascade when investigating the molecular mechanism of renal protection against nephrotoxicity (El-Sayed et al., 2024). baseball party

Molecular mechanisms of cisplatin-induced …

Cisplatin nephrotoxicity: new insights and therapeutic …

http://www.bccancer.bc.ca/drug-database-site/Drug%20Index/Cisplatin_monograph.pdf WebThe mechanisms mainly include the transport and metabolism of cisplatin, apoptosis, autophagy, DNA damage, oxidative stress, and inflammation, which work together to … svrsvrWebOct 13, 2024 · Preclinical studies have provided insights into the cellular and molecular mechanisms of cisplatin nephrotoxicity, which involve intracellular stresses including … svrsvcsetup エラー

"WebDec 16, 2024 · Introduction. Cisplatin is commonly applied in the treatment of a diversity of solid tumors in medical practice due to its simple administration and great efficacy. 1 Cisplatin efficiency is proportionate to its dose. Nevertheless, cisplatin has a relatively limited safety margin and exhibits significant dose-limiting side effects, such as vomiting, … " - Cisplatin induced nephrotoxicity mechanism

Cisplatin induced nephrotoxicity mechanism

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WebMar 23, 2024 · For nearly five decades, cisplatin has played an important role as a standard chemotherapeutic agent and been prescribed to 10-20% of all cancer patients. Although nephrotoxicity associated with platinum-based agents is well recognized, treatment of cisplatin-induced acute kidney injury is mainly su … WebMay 1, 2008 · Overview of the pathophysiological events in cisplatin nephrotoxicity. Cisplatin enters renal cells by passive and/or facilitated mechanisms. Exposure of …

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WebThe mechanisms of cisplatin-induced nephrotoxicity are complex and involve multiple pathways and molecules ( Figure 1) [ 92, 93 ]. The cellular pathways of cisplatin injury … WebDiscussion. In a previous study, we showed that DM was the high-risk factor for cisplatin-induced AKI. 5 However, no attempt was made to identify the mechanism for the …

WebJan 3, 2024 · Chemotherapy nephrotoxicity and dose modification in patients with kidney impairment: Molecularly targeted agents and immunotherapies; Cisplatin nephrotoxicity; Classic Kaposi sarcoma: Clinical features, staging, diagnosis, and treatment; Contrast-associated and contrast-induced acute kidney injury: Clinical features, diagnosis, and … WebJul 22, 2024 · Cisplatin is a potent and valuable chemotherapy agent used to treat a broad spectrum of malignancies. Renal tubular dysfunction and a cumulative impairment in kidney function, as manifested by a decline in the glomerular filtration rate (GFR), can be dose … {{configCtrl2.info.metaDescription}} Nephrotoxicity from chemotherapeutic agents: clinical manifestations, … Ultrafilterable platinum (UP) disposition was studied in 22 cancer patients receiving … The lowest dose categories of cisplatin (≤100 and 101-250 mg/m(2)) are … Faubel S, Ljubanovic D, Reznikov L, et al. Caspase-1-deficient mice are protected …

WebOct 5, 2014 · Cisplatin induced toxicities, especially nephrotoxicity, seem to be related to a decrease in the intracellular concentrations of GSH and protein bound SH-groups. …

WebFeb 24, 2024 · The mechanism of cisplatin-induced renal injury is unclear but appears to be associated with abnormal vacuolization and damage of the proximal tubule ( 17 ). Recent years have seen growing interest in kidney-on-a-chip technology ( 18, 19 ).

WebOct 26, 2024 · Background . Cisplatin is a powerful chemotherapeutic drug mainly used in the treatment of solid tumors. Aggregation of the drug in renal proximal tubule cells causes nephrotoxicity and renal failure. Investigations showed nephrotoxicity as Cisplatin’s dose-limiting side effect. One of the Cisplatin toxicity mechanisms is generation of … svr svri 正常値WebFeb 2, 2024 · The mechanisms of cisplatin-induced acute kidney injury (AKI) are complex, and there are limited renoprotective approaches. Leonurine is the main active compound of a Chinese herb and has recently been … svr svriWebMay 22, 2024 · Bismuth Porphyrin Antagonizes Cisplatin-Induced Nephrotoxicity via Unexpected Metallothionein-Independent Mechanisms Bismuth Porphyrin Antagonizes Cisplatin-Induced Nephrotoxicity via Unexpected Metallothionein-Independent Mechanisms iScience. 2024 May 22;23 (5):101054. doi: 10.1016/j.isci.2024.101054. … svr svri normal values