WebChrysotoxine (CTX), a naturally occurring bibenzyl compound isolated from Dendrobium species, has been reported to have neuroprotective effects. To evaluate its pharmacokinetics in rats, a rapid, sensitive and specific high performance liquid chromatography-tandem mass spectrometric (HPLC-MS/MS) method has been … WebNov 2, 2024 · Methods: The chemical constituents from the EtOAc fraction of ethanol extract from pseudobulbs in P. bulbocodioides were isolated and purified by various chromatographic methods, including silica...
Chrysotoxine, a novel bibenzyl compound selectively
WebNov 1, 2010 · Chrysotoxine structure-specifically attenuates 6-OHDA-induced neurotoxicity. Chrysotoxine direct scavenges intracellular ROS induced by 6-OHDA, thus blocks ROS-mediated downstream signaling pathways. Mitochondria protection and NF-κB modulation may be involved in the protective mechanism. Introduction WebCTX can serve as a promising drug target for treating anesthetics-induced neurotoxicity and ameliorated neurotoxicity through activating the PI3K/AKT/GSK signaling pathway. Objective: The aim of this study is to investigate the neuroprotective effect of chrysotoxine (CTX) on sevoflurane-treated nerve cells and uncover the potential regulation … can i buy crypto on ameritrade
Determination of chrysotoxine in rat plasma by liquid
WebOur investigation of the stem of Dendrobium pulchellum resulted in the isolation of four known bibenzyls, chrysotobibenzyl (1), chrysotoxine (2), crepidatin (3) and moscatilin (4). The present study reveals for the first time the ability of these four compounds to facilitate anoikis and inhibit the … WebChrysotoxine is a naturally occurring bibenzyl compound found in medicinal Dendrobium species. We previously reported that chrysotoxine structure-specifically suppressed 6-hydroxydopamine (6-OHDA)-induced dopaminergic cell death. Whether chrysotoxine and other structurally similar bibenzyl compounds could also inhibit the neurotoxicity of 1 ... WebJul 8, 2024 · Objective: The aim of this study is to investigate the neuroprotective effect of chrysotoxine (CTX) on sevoflurane-treated nerve cells and uncover the potential regulation mechanism. Methods: Nerve cells treated with sevoflurane and CTX were subjected to MTT and apoptotic detection. fitness motivation women beautiful